5+ day, 13+ hour ago   (196+ words) Inside Precision Medicine Writing in JAMA Network Open, Matthew Krantz, MD, from Vanderbilt University Medical Center, and co-authors explain that drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe, potentially fatal drug hypersensitivity reaction characterized by extensive skin…...

1+ week, 6+ day ago   (424+ words) Heart failure has no shortage of effective drugs. The bigger problem is getting patients onto them. A new Nature Medicine study takes a precision medicine approach to that problem. Researchers pooled individual-level data from 38,753 participants across nine major randomized heart…...

2+ week, 6+ day ago   (360+ words) University of Michigan researchers have developed a new way to exploit a decades-old target in the quest for a universal flu vaccine, using baker’s yeast to produce virus-like particles displaying full-length M2, a highly conserved influenza protein. In mice, the experimental…...

3+ week, 2+ day ago   (252+ words) An oral small molecule that increases energy expenditure rather than suppressing appetite produced substantial weight loss while preserving lean mass in mouse models of obesity, suggesting a potentially complementary strategy to GLP-1–based therapies. In mice with high-fat diet-induced obesity,…...

3+ week, 2+ day ago   (225+ words) Rare disease specialist Ultragenyx’s gene therapy Genglycos has received accelerated approval from the FDA for treatment of glycogen storage disease type Ia (GSDIa), a rare metabolic condition. This marks the fifth FDA approval for the California-based biotech, which has already…...

3+ week, 5+ day ago   (481+ words) Researchers in Australia have developed a gene therapy that could restore heart function in children born with mutations that cause cardiomyopathy. A study published in Nature Cardiovascular Research suggests this approach could potentially address more than 25% of cardiomyopathies that have…...