5+ day, 19+ hour ago   (340+ words) Genetic variants commonly found in people of European descent are associated with accelerated progression of Parkinson’s disease (PD), research indicates. The findings, in JAMA Neurology, suggest common loss-of-function variants in the melanocortin 1 receptor (MC1R) gene, carried by more than 60% of individuals…...

1+ week, 2+ day ago   (450+ words) Reactive oxygen species are usually cast as the villains in cancer, capable of damaging DNA and promoting tumor growth. But new research shows that cancer-fighting T cells need small amounts of these molecules—and tumors may exploit that dependence to…...

1+ week, 5+ day ago   (443+ words) Two recent clinical readouts highlight both the promise and limitations of therapeutic cancer vaccines. The divergent outcomes sharpen a key question for the field: Is generating tumor-specific immunity enough, or must cancer vaccines also create conditions in which that immunity…...

2+ week, 4+ day ago   (419+ words) Researchers from the University of Exeter in the U.K. have shown that incorporating a type 1 diabetes genetic risk score (T1DGRS) into standard testing for maturity-onset diabetes of the young (MODY) could identify hidden type 1 diabetes in around one in six patients with…...

2+ week, 4+ day ago   (246+ words) “What we are doing is developing a personalized but off-the-shelf cellular immunotherapy for cancer,” William V. Williams, MD, told Inside Precision Medicine. Williams is president and chief executive officer of BriaCell Bria-MEL+ is a cell-based therapeutic cancer vaccine designed to…...