1+ hour, 32+ min ago   (405+ words) Maintaining muscular strength could be vital for older women to age healthily, protecting them from death even when their fitness levels are below par. The findings, in JAMA Network Open, support guidelines that encourage muscle strengthening activities to age well…...

12+ hour, 32+ min ago   (174+ words) Clinically relevant cutoffs were derived using the Youden index, yielding thresholds of 0.24 pg/mL for p-tau217 in Alzheimer's and 21.91 pg/mL for NfL in FTLD. Notably, the p-tau217 threshold closely mirrors values reported in high-income countries, suggesting cross-population stability despite substantial heterogeneity....

1+ day, 21+ hour ago   (216+ words) In a clinical first, Tr1X Bio showed immune reconstitution and engraftment for allogeneic Tr1 cell therapy, establishing clinical safety and efficacy By Jonathan D. Grinstein, PhD Tr1X was founded just over four years ago with a singular goal of moving away from chronic treatment…...

1+ day, 23+ hour ago   (447+ words) The paper appeared January 26 in Nature Cancer, and the lead author is Jason Vassy, MD, a physician-scientist with the VA Boston Healthcare System and Mass General Brigham, associate professor of medicine at Harvard Medical School, and leader of the ProGRESS…...

2+ day, 2+ hour ago   (613+ words) DNA barcoding can reflect the complex cellular makeup of cancerous tumors, according to a study that could help drive the development of precision oncology. The findings, in Molecular Systems Biology, indicated that, while both solid biopsies and those from blood…...

2+ day, 2+ hour ago   (739+ words) Inherited VSIG10L Mutations Linked to Barrett's Esophagus and Cancer Risk'Inside Precision Medicine Researchers at Case Western Reserve University have discovered genetic mutations in a gene that place people at higher risk of developing Barret's esophagus, a condition that greatly increases the…...

2+ day, 3+ hour ago   (323+ words) This is precision medicine for trauma," said Kirk Hansen, PhD, professor of biochemistry at CU Anschutz and a senior author of the study. By combining proteomics and metabolomics data, we can not only predict outcomes more accurately than traditional methods,…...

2+ day, 4+ hour ago   (581+ words) A polygenic risk score (PRS) created using genetic information from more than 35,000 women of African ancestry more accurately predicts breast cancer risk in these women than standard models that typically use data from women of European descent. Huo and co-investigators…...

2+ day, 5+ hour ago   (399+ words) Glioblastoma is the most common and deadliest brain cancer, with about 14,000 new diagnoses each year in the U.S. Survival after diagnosis is typically about 15 months, and standard treatments such as surgery, radiation, and chemotherapy extend life only modestly. Temozolomide, the most…...

2+ day, 5+ hour ago   (829+ words) A new study is reshaping how researchers think about the earliest steps of pancreatic cancer progression, revealing that sympathetic nerves and cancer-associated fibroblasts collaborate far earlier than expected to fuel disease growth. "We were not expecting that," said J'r'my Nigri,…...