1+ day, 3+ hour ago   (55+ words) Gene editing has long promised a revolution in cancer medicine, yet the promise has remained stubbornly out of reach for one deceptively simple reason: getting the CRISPR-Cas9 machinery into tumor cells, and only tumor cells, is extraordinarily difficult. A new…...

1+ day, 21+ hour ago   (48+ words) Targeted lipid nanoparticles deliver mRNA to tumor-associated macrophages, reprogramming the immune environment and strengthening anti-cancer T-cell activity in mice. Smart nanoparticles reprogram tumor immune cells to boost cancer attack Targeted lipid nanoparticles deliver mRNA to tumor-associated macrophages, reprogramming the immune…...

1+ day, 14+ hour ago   (69+ words) A receptor long viewed as one of the more enigmatic members of the lipid-sensing G protein-coupled receptor family is now coming into sharp molecular focus. New research published in Experimental & Molecular Medicine describes how structural snapshots of GPR84, captured in distinct…...

2+ day, 34+ min ago   (67+ words) Cancer has long been understood as a disease of the genome, driven by mutations that rewire the instructions encoded in DNA. Over the past three decades, however, a parallel truth has crystallized: cancer is equally a disease of the epigenome,…...

2+ day, 1+ hour ago   (736+ words) Chronic hepatitis B virus infection remains one of the most stubborn immunological challenges in medicine, largely because the CD8+ T cells that should destroy infected liver cells gradually lose their killing power....