1+ day, 8+ hour ago  (182+ words) Perioperative anticoagulation management is increasingly guided by recommendations from multiple specialties, including cardiology, thrombosis medicine, stroke medicine, and surgery. These frameworks, while intending to improve standardization of interruption and resumption strategies for antithrombotic therapy, are largely centered on surgical bleeding…...

1+ day, 8+ hour ago  (357+ words) Objective: Unintended dural puncture (UDP) and failed neuraxial anesthesia increase risks for conversion to general anesthesia, procedural delays, and patient dissatisfaction. Additionally, UDP can result in a postdural puncture headache (PDPH) with significant maternal morbidity. Factors such as clinician experience,…...

3+ day, 8+ hour ago  (260+ words) Background Depression is a multifactorial neuropsychiatric disorder involving alterations in neuroplasticity, neurotransmission, and oxidative stress. Zebrafish larvae are a useful model for studying stress-induced behavioral changes. Pithecellobium dulce, rich in bioactive phytochemicals, has reported antioxidant properties, but its effects in…...

3+ day, 8+ hour ago  (201+ words) Colorectal cancer (CRC) diagnosed in individuals under 50 years of age is referred to as early-onset CRC. In recent decades, a significant increase in both its incidence and mortality has been observed. These patients are frequently diagnosed at advanced stages, which…...

8+ hour, 9+ min ago  (480+ words) Background Neurological manifestations are a significant cause of morbidity among individuals'living with HIV. In many clinical settings, particularly where access to advanced neuroimaging and cerebrospinal fluid diagnostics is limited, risk stratification often relies on CD4 count and routinely available laboratory parameters....

8+ hour, 9+ min ago  (168+ words) Ankyloglossia restricts tongue mobility and may impair speech, oral hygiene, and quality of life. Lasers offer advantages over scalpel techniques, including hemostasis and improved patient comfort. This report presents three cases of Kotlow Class II and III ankyloglossia treated with…...

6+ hour, 26+ min ago  (228+ words) Drug-induced liver injury (DILI) is hepatic damage caused by medications, illegal drugs, herbal products, or dietary supplements and is related to inflammation, oxidative stress, and mitochondrial dysfunction. Manifestations can vary from isolated liver enzyme elevation to fulminant hepatic failure. As many…...

21+ hour, 16+ min ago  (206+ words) Introduction Extranodal presentation of non-Hodgkin's lymphoma (NHL) poses a diagnostic challenge due to its diverse clinical, morphological, and pathological features. These lymphomas arise in organs other than lymph nodes. Immunohistochemistry (IHC) plays a crucial role in the confirmation and subtyping…...

1+ day, 8+ hour ago  (154+ words) Pentalogy of Cantrell is a rare congenital anomaly characterized by a spectrum of midline thoracoabdominal defects involving the abdominal wall, sternum, diaphragm, pericardium, and heart. We report a case of a 32-year-old primigravida diagnosed during a routine second-trimester anomaly scan…...

12+ hour, 26+ min ago  (294+ words) Calcitonin, a peptide hormone produced by thyroid parafollicular cells, is used clinically for acute hypercalcemia, Paget's disease of bone, and, less commonly, postmenopausal osteoporosis. It also has recognized analgesic utility in select pain syndromes. Although its skeletal actions are well…...