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Parkinson’s disease affects network of brain regions that controls whole-body action
31+ min ago (176+ words) Expert opinion" is published under a CC BY 4.0 licence, Figure 1 is published under a CC BY-NC-ND 4.0 licence. Sveinbjornsdottir, S. J. Neurochem. 139, 318324 (2016). Gordon, E. M. et al. Nature 617, 351359 (2023). Shen, L. et al. Ann. Neurol. 88, 11781193 (2020). Dahmani, L. et al. npj Parkinsons Dis. 9, 90 (2023). Ren, J. et al. Brain Stimul. 16, 13131321 (2023). Brains…...
OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours
1+ hour, 8+ min ago (1752+ words) Vivier, E., Tomasello, E., Baratin, M., Walzer, T. & Ugolini, S. Functions of natural killer cells. Nat. Immunol. 9, 503510 (2008). Ben-Shmuel, A., Biber, G. & Barda-Saad, M. Unleashing natural killer cells in the tumor microenvironment'the next generation of immunotherapy?. Front. Immunol. 11, 275 (2020). Guillerey, C., Huntington, N. D. & Smyth, M. J. Targeting natural killer cells in cancer immunotherapy. Nat....
MicroRNA-132/212 negatively modulates opioid reward by targeting dopamine transporter in the ventral tegmental area - Translational Psychiatry
5+ hour, 17+ min ago (504+ words) Addictive drugs, notably opioid drugs, have significant societal implications, yet the cellular and molecular mechanisms underpinning rewarding effects remain largely elusive. Noncoding transcripts, including the microRNAs (miRNAs), are pivotal regulators of diverse biological functions. Notably, the microRNAs miR-132 and miR…...
Collection Policies | Viral infections and the nervous system
5+ hour, 23+ min ago (332+ words) Collection Policies | Viral infections and the nervous system'Nature Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser…...
Nitric Oxide-Mediated S-Nitrosylation of TSC2 Drives mTOR dysregulation across Shank3 and Cntnap2 Models of Autism Spectrum Disorder - Molecular Psychiatry
5+ hour, 26+ min ago (1818+ words) Tissue/cells were lysed in the lysis buffer and centrifuged at 17,000g for 30min at 4C to remove insoluble matter. The experiment was performed with the Immunoprecipitation Kit-Dynabeads Protein G according to the protocol(10007D). Immunoprecipitation was done for the TSC2, and then immunoblotting was…...
Dual regulatory roles of CPT1C in chronic stress-induced depression-related outcomes - Molecular Psychiatry
5+ hour, 49+ min ago (1788+ words) The raw data and Western blot images generated in this study are provided in the Supplementary Information/Source Data file. Further information generated in this study is available from the corresponding author upon request. Source data are provided in this…...
Landmark Papers in Oral and Maxillofacial Surgery - BDJ Student
6+ hour, 32+ min ago (73+ words) BDJ Student (2026)Cite this article Compiled by Pete Folly, Library Manager, British Dental Association Tom Pepper, Clare Schilling, and Mehmet Manisali (2026) You can access this e-book here. Your BDA Library service is available at the touch of a button - our…...
The predictive value of polygenic risk scores for depression in gene-environment interaction studies: a systematic review - Translational Psychiatry
7+ hour, 35+ min ago (1749+ words) While most studies reported significant main effects of an individual's PRSD and different environmental exposures on depression phenotypes, the overall evidence for GxE interactions was considerably heterogeneous. Findings of significant PRSDxE interactions mostly stem from large cohort studies comprising > 40000 participants,…...
Myelin dysfunction in autism spectrum disorder: insights into core symptoms and mechanisms of brain development - Molecular Psychiatry
8+ hour, 14+ min ago (1616+ words) Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition with multifactorial etiologies. Although much research has historically focused on neurons, growing evidence indicates that multiple cell types within the central nervous system (CNS), particularly glial cells, also play critical roles....
Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppression - Cell Death Discovery
8+ hour, 20+ min ago (1795+ words) Cell Death Discovery , Article'number:' (2026) Cite this article All data and materials are included in this manuscript. Reagents associated with this study are available from the corresponding author upon request. RNA-seq data generated in this study have been deposited in the…...